http://swrc.ontoware.org/ontology#Misc Medical expert system for early stage of chronic kidney disease (CKD) en Machine learning algorithm Medical expert system Chronic kidney disease Decision-making ability Choo Jun Tan Ping Chow Teoh Expert systems (Computer science) WOU Medical Expert System (MES) is a computer system that emulates the decision-making ability of a medical expert. MES is designed to tackle the complex problem of Chronic Kidney Disease (CKD). It adopts Machine-Learning (ML) algorithm, which has the ability to learn without being explicitly programmed in application level. ML evolved from the study of pattern recognition and computational learning theory in artificial intelligence. ML aids MES to learn from the given historical data and make predictions based on incoming new data from laboratory results. Reasoning method with ML was performed on the selected known facts that caused CKD. Experiment with a sample of 400 patients in an early diagnosis stage from a designated hospital was conducted. MES has recorded an accuracy rate of 99.25% in the 10-fold Cross Validation based knowledge updating processes. Electronic Penang International Science Fair (SPICE Arena, Penang : 12-13 November 2016) Wawasan Open University